ISSN: 1935-1232 (P)

ISSN: 1941-2010 (E)

Isam Hamo Mahmood
Department of Pharmacology, University of Al Noor, Bartella, Iraq


  • Research   
    Evaluation of Cytotoxic Effect of Metformin on a Variety of Cancer Cell Lines
    Author(s): Abdel Rasool* and Isam Hamo Mahmood

    Summary Metformin is an oral hypoglycaemic and anti-diabetic medication. Metformin suppresses cancer cell development and reduce the amounts of stimuli that promote cell proliferation. Cancer is a category of diseases marked by the uncontrollable development and spread of abnormal cells. This study was aimed to determine the efficacy of metformin cytotoxicity on a variety of cancer cell lines. In this study methods used serious metformin concentrations (0, 5, 10, 15, 25, 35, 65, 130 μM) on a variety cells (Hela, AMJ3, HCAM, A172, HBL100) were incubated for 48,72 hours, We utilize the MTT assay to determine the viability of cancer cells, which is a typical test for determining the cytotoxic effects. Analysis indicated that populations of cancer cells was lowering the results revealed significant reduce viability of cancer cell line had highly significant cytotoxic eff.. Read More»

    Abstract HTML PDF