ISSN: 1935-1232 (P)

ISSN: 1941-2010 (E)

Hadeel Alaa Al-Rrubaei
Deparment of DNA Research Center, University of Babylon, Hillah, Iraq


  • Research   
    Association of ROS Level with Some DNA Repair Genes Polymorphisms in Type 1 Diabetes Mellitus Patients
    Author(s): Mona N. Al-Terehi*, Hadeel Alaa Al-Rrubaei and Noora M. Hameed

    The ROS is most problems in some disease and have major role disease development; DNA repair genes have been associated with different disease in addition to related with ROS, the present study aims to study ROS level with some DNA repair genes polymorphisms in patient with type 1 diabetes mellitus patients, the OGG1 Ser326Cys (rs1052133) and APE1 Asp148Glu (rs3136820), the results show that ROS level was significant elevation in patients 196.3600 ± 90.039 than control 95.37 ± 13.22, the genotyping of APE1 shows three genotyping (GT,GG and TT) with tow alleles (G and T), GT was low frequents in patients while TT was higher in patients than control in non-significant differences (p 0.38, 0.50) , T is more frequent in patients in addition to G was low frequent also in on significant differences (p 0.0513 ) in addition to deletion mutation which significant asso.. Read More»

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