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ISSN: 1935-1232 (P)

ISSN: 1941-2010 (E)

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Google Scholar citation report
Citations : 5129

Clinical Schizophrenia & Related Psychoses received 5129 citations as per Google Scholar report

Clinical Schizophrenia & Related Psychoses peer review process verified at publons

Indexed In

 
Eman Tareq Mohammed
Nineveh, Iraq

Publications

  • Research   
    Mutual Prodrug of 5-Ethynyluracil and 5-Fluorouracil: Synthesis and Pharmacokinetic Profile
    Author(s): Yasser Fakri Mustafa*, Mahmood Khudhayer Oglah, Moath Kahtan Bashir, Eman Tareq Mohammed and Raghad Riyadh Khalil

    The oral administration of the standard cytotoxic agent 5-fluorouracil is extensively limited in the last three decades. This restriction is due to the drug's uneven intestinal absorption due to the changeable activity of dihydropyrimidine dehydrogenase, an enzyme found in the intestinal mucosa. A prodrug containing 5-fluorouracil and 5-ethynyluracil was developed in this study to allow mutual release of these two active medicines via a lactonizationfacilitated release mechanism. Using coumarin as a precursor, the synthesis of the target prodrug was carried out in seven stages. The chemical backbones of the synthesized intermediate molecules and the target prodrug were verified using spectra acquired from several spectrophotometers,including FTIR, 1H-NMR, and 13C-NMR. In the HCl- (pH 1.2) and phosphate- (pH 6.8) buffers, the target prodrug's chemical stability was stu.. Read More»

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