Arkhipov Andrei Yurevich

Department of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

Publications

• Research Article   
  Incongruence of Neurophysiological Manifestations as Reflection of Disturbances in Synaptic Pruning of the Cortex in Paranoid Schizophrenia
  Author(s): Arkhipov Andrei Yurevich*, Nurbekov Malik Kubanichbekovich and Strelets Valeria Borisovna
  
  Current study provides a comprehensive analysis of neurophysiological and molecular genetic data concerning the etiology of hallucinatory-paranoid syndrome in schizophrenia. The level of cortical excitation and inhibition was determined by analysis of Event-Related Potential (ERP) parameters: latency and amplitude of intermediate (P200) and late (P300, N400) ERP components. The results showed the impossibility to determine the level of different cortical areas activation during perceiving stimuli of different significance in patients with hallucinatory-paranoid syndrome due to unidirectional shift of both ERP parameters to significant stimuli. The observed simultaneous increase of both amplitude and latency of these components in frontal regions is associated with an excessive number of aberrant synapses, and a decrease in the central regions is associated with synaptic deficit, this .. Read More»
  DOI: 10.3371/CSRP.YAKN.092722

  Abstract HTML PDF