Multicommodity of Human Immunodeficiency Virus, Human Herpesvirus Seven and PolyneuropathyAuthor(s): Lourdes de Fatima Ibanez Valdes, Sibi Sebastian Joseph and Humberto Foyaca Sibat*
Background: One of the associated conditions seen in HIV patients is PN which is a relatively common neurologic disorder with subvariants involving the sensory, motor somatic and motor autonomic pathways, being the distal symmetric PN the most frequently seen PN subtype presents length-dependent symptoms because the longest nerves are affected first and sensory-predominant plus sensory-motor signs. Human Herpes viruses (HHV) are double-stranded DNA viruses able to cause a wide range of clinical manifestations, from vesicular rashes to malignant disorders. The primary aid of this study is to review the medical literature related to the comorbidity of HIV/HHV7/ PN, report a case and formulate some hypotheses about the pathogenesis of these associated diseases.
Methods: We searched the medical literature comprehensively, looking for published Medical Subject Heading (MeSH) terms like "HIV-Polyneuropathy; OR "Human Herpes Virus 7", OR "Comorbidity HIV/HHV7 disorders"; OR "Pathogenesis of HIV/HHV7/PN", OR "HIV/HHV7/Cytokine/Chemokine", OR "Posterior Horn Spinal Cord, Posterior Root Ganglion Viral Infections" OR "Immunological disorders of PHSC/PRG/PN."
Results: All selected manuscripts were peer-reviewed, and we did not find publications related to HIV/HHV7/PN
Comments and concluding remarks: As far we know, this is the first case presenting the comorbidity of HIV/HHV7/PN responding remarkably to Acyclovir and rituximab reported in the medical literature. The authors also released some hypotheses related to the pathogenesis of this comorbidity.