ISSN: 1935-1232 (P)

ISSN: 1941-2010 (E)

Shakir Ullah
Dr, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar KP, Pakistan


  • Research   
    Distribution of Different Genotypes MTHFR and GABRG2 Genes in Epileptic Population of Khyber Pakhtunkhwa Pakistan
    Author(s): Shakir Ullah*, Niaz Ali, Saad Ali, Adnan Khan, Sajjad Ahmad and Zia uddin

    Objectives: The present study determines the frequencies of different types of resistant epilepsies to carbamazepine and valproic acid therapy in population of Khyber Pakhtunkhwa. The study also determines the frequencies of MTHFR (C677T, A1298C) and GABRG2 (C588T, C315T) genes polymorphisms in population of KP as the said genes have role in management of epilepsies. Materials and methods: Epileptic patients treated with carbamazepine and valproic acid therapy were enrolled in the study. DNA was extracted from the blood and genotyped for the MTHFR and GABRG2 genes polymorphisms using restriction fragment length polymorphisms (PCR-RFLP). Seizure control and adverse drug reactions were recorded during the treatment. Results: There were 64% males and 34% females. Frequency of PGS was 79% of epilepsies. Heteroz.. Read More»

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