Munn Sann Lye

Publications

• Research Article   
  Personality Trait and Antidepressant Type are Potential Moderators of the Association between Genotypes of HTR1A-rs6295 or HTR2A-rs6311 with Treatment Response
  Author(s): Ibrahim Mohammed Badamasi*, Munn Sann Lye, Normala Ibrahim, Nurul Asyikin Abdul Razaq, King Hwa Ling and Johnson Stanslas
  
  Background: Currently, empiric treatment of Major Depressive Disorder (MDD) relies on the characteristics of the presenting patients. Aim: The aim of the current study was to identify moderators for the association of SSRI treatment efficacy response phenotype with genotypes of HTR1A-rs6295 or HTR2A-rs6311 polymorphism in a population of MDD patients. Materials and methods: The study included 300 patients with MDD. The assessment of Selective Serotonin Reuptake Inhibitors (SSRI) treatment response was based on 50% reduction in the depressive score obtained within 6 weeks of treatment onset on the Montgomery Asberg Depression Rating Scale (MADRS-S) for each patient recruited in the psychiatric clinics of the four tertiary hospitals in the Klang valley region of Malaysia. Results: .. Read More»
  

  Abstract HTML PDF