Kulwant Buttar

Department of Psychiatry, School of Medicine, State University of New York at Buffalo, New York, USA

Publications

• Case Report   
  Successful Treatment of a Treatment Refractory Patient with Clozapine Retrial
  Author(s): Kulwant Buttar, Jeffery J Grace and Eileen Trigoboff*
  
  This case study presents a paradigm for a clozapine retrial to treat and help a seriously ill treatment-resistant psychiatric patient, particularly in the context of rare genetic disorders. This patient’s bizarre behavior included sustained and remarkable retropulsion, disrobing, unprovoked striking out at others, urinating and defecating in inappropriate places, mutism, and lying on the floor of the hallway for extended periods of time. Multiple diagnoses as well as varied and extensive genetic and psychopharmacological treatment resulted in an interrupted clozapine induction trial producing the only improvement. That incomplete trial had to be discontinued due to leukopenia. The case is particularly noteworthy for its comprehensive diagnostic workup, leading to the identification of a novel PDGFRB gene mutation associated with Primary Familial Brain Calcification (PFBC). The m.. Read More»
  

  Abstract PDF