Tuberous Sclerosis and Psychosis Comorbidity with Concurrent Hypersexuality: A Case ReportAuthor(s): Shain Michael J, Mian Taimur, Cunningham Ann and Goheer Sadia*
Tuberous Sclerosis (TS) is a rare genetic disorder that affects 40,000-80,000 people in the United States (total prevalence) that is mainly characterized by development of tumors in different parts of the body. Other well-known disease components include intellectual disability (likely an Autism Spectrum Disorder), ADHD, ash-leaf spots, shagreen patches, and epilepsy. Multiple cases have also been documented of patient developing psychosis secondary to TS. Although TS associated neuropsychiatric disorders have been described, a clear association between tuberous sclerosis and psychosis has not been established. We present a case of a 21-year-old male with a history of TS and Intellectual disability who presented with a chief complaint of suicidal thinking and symptoms of visual and command auditory hallucinations of a demon. His presentation was unique and challenging to manage as the patient lacked executive function, resulting in hyper sexuality and impulsivity. Clinicians should be aware of the association of TS with psychotic symptoms, and the unique challenges in their management.