Abstract
Novel Hypotheses on the Role of Microglia and PANoptosis in Neurocysticercosis
Author(s): Lourdes de Fatima Ibanez Valdes and Humberto Foyaca Sibat*Background: Cysticercosis (Ct) is a preventable and eradicable zoonotic parasitic disease secondary to an infection caused by the larva form of pig tapeworm Taenia solium (Ts), mainly seen in people living in developing countries. However, the number of carriers in developed countries has increased gradually due to globalization and uncontrolled migration. In this study, we look for the role Microglia (Mg) played in the pathogenesis of Neurocysticercosis (NCC). After viewing this issue, we formulate some hypotheses regarding the role of Mg, trained immune response and PANoptosis in NCC.
Methods: We searched the medical literature comprehensively, looking for published Medical Subject Heading (MeSH) terms like "Neurocysticercosis", "pathogenesis of neurocysticercosis", "comorbidity in NCC", OR "Apoptosis", "Pyroptosis," OR "Necroptosis;" OR "PANoptosis;" OR "PANoptosome;" OR "Reprogramming Somatic Cells."
Results: All selected manuscripts were peer-reviewed, and we did not find publications related to Mg/Ap/Pp/Np/PANp/PANop/RSC/NCC.
Conclusion: We have hypothesized the role of Mg on the pathogenesis of cysticercus perilesional oedema and the role of Mg during NCC's colloid/nodular stage.