Exosomes Applications in Parkinson's DiseaseAuthor(s): Junzheng Yang* and Zhenghai Li
Exosomes are a kind of small membrane vesicles with the diameter of 30 nm to 150 nm containing complex RNAs or proteins, which could be secreted by cells under normal and pathological conditions. It has been reported that exosomes could play an important role in cell-cell communication, signaling pathway regulation, disease diagnosis and disease treatment; exosomes have been applied in many fields including clinical diagnosis, immunotherapy and tissue repair. Parkinson's disease as a kind of neurogenerative diseases, it has a high incidence rate in the elderly people, and there is no ideal treatment. The main pathological change of Parkinson's disease is the degeneration and death of dopaminergic neurons in the substantia nigra of the midbrain, which leads to the significant reduction of dopamine in the striatum. Here, we will introduce exosomes applications in Parkinson's disease, which may provide some new idea for Parkinson's disease treatment.