ISSN: 1935-1232 (P)

ISSN: 1941-2010 (E)

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Citations : 5129

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Association of 8-Oxo-2'-Deoxyguanosine, hOGG1 Ser326Cys Gene Polymorphism with Reactive Oxygen Species in Depression Patients
Author(s): Mona N Al‐Terehi*, Abed J Kadhim, Israa Harjan Mohsen, Marwa Fadhil Alsaffar, Shakir Atiyah, Saif Yaseen Hasan, Doaa A Hamad, Ghadeer Sabah Bustani, Saif Aldeen Muhannad Abdullah and Rehab Subhi Ramadhan

The present work was suggested to study the relation 8-Oxo-2'-deoxyguanosine (8-oxo-dG) with ROS level and hOGG1 gene polymorphism in depression disorder patients, blood samples were collected from study groups to estimate ROS and 8-oxo-dG in addition to DNA extraction to detection hOGG1 Ser326Cys polymorphism using SSCP technique, The results show that there was non-significant in 8-oxo-dG level (P=0.174) and significant differences (P=0.174) in ROS level in study groups, The correlation coefficient between ROS and 8-oxo-dG in shows weak positive correlation in patients group (r-0.188, P 0.426) and nonsignificant weak invers corelation in control group (r-0.074, P 0.719), the target sequence of hOGG gene was amplified to produced 290 pb and genotyping shows three patterns include (3,2 and single haplotype). The pattern of 3 haplotypes didn't observed in patients while appeared in high percentage of control (61.535%) in significant differences (P=0.0046), the 2 haplotypes pattern was more frequent in patient (73.68%) than control group (7.69%) in significant differences (P 0.010), the single haplotypes was recorded in low percentage in patients (26.31%) than control group (30.76%),The impact of hOGG1 gene polymorphisms in the 8-oxodG and ROS levels show non-significant differences among haplotypes, the 2 haplotypes causes elevation in the 8-oxo-dG in patients while causes decrement in control group, the single haplotypes causes decreasing in the 8-oxo-dG in patients than control group and finally slightly differences were observed in ROS level among haplotypes in study groups. From present study can be concluded the 8-oxo-dG and ROS were strong related with depression and strong associated with OGG1 Ser326Cys gene polymorphism.