Abstract

Background: Globally, the use of contraception has been increased due to a serious problem facing the world which is population explosion. It has been suggested that the use of contraceptives is beneficial, but it has some side effects and metabolism impairment too. The most accepted and widely used birth control to avoid unintended pregnancy is Combined Oral Contraceptive Pills (COCPs).

Objective: To evaluate serum lipid profile level in females receiving COCPs at reproductive age. To assess association between the duration of the use of COCP with serum lipid profile.

Patients and methods: A case control study was conducted at Thumbay Hospital in Ajman, UAE. A total of 99 women were enrolled in the study. The participants were divided into two groups, (COCPs users, n=49) received monophasic COCP (Yasmin), which contains 3 mg prospirenone and 0.03 mg ethinyl estradiol and (Non-users, n=50) as a control.

Results: The results showed statistically significant differences among COCPs users compared with non-users. There was significant increase of Total Cholesterol (TC) (198.0 ± 33.0 mg/dl vs.176.7 ± 28.2 mg/dl; p=0.001), Triglyceride (TG) (112.4 ± 54.6 mg/dl vs.98.1 ± 54.4 mg/dl; p ≥ 0.05), High Density Lipoprotein (HDL-C) (60.1 ± 19.6 mg/dl vs.53.1 ± 13.7 mg/dl; p=0.04), BMI (28.4 ± 4.9 vs.28.0 ± 5.3 Kg/m2 ; p=0.55) was not significant.

According to duration of COCPs intake, there was statistically significant increase in Low Density Lipoprotein (LDL-C) (102.1 ± 31.8 mg/dl vs.123.9 ± 23.1 mg/dl; p=0.017).

Conclusion: Significantly elevated lipid profile and non-significant increase of BMI were recorded among COCPs users.

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