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ISSN: 1935-1232 (P)

ISSN: 1941-2010 (E)

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Abstract

Psychosis Following the Addition of Pramipexole in an Intellectually Disabled Adult

Author(s): Nancy C. Brahm, Gary A. Fast, Robert C. Brown

A fifty-six-year old verbal male with moderate mental retardation (IQ range of 35-40 to 50-55) residing in a state-run facility developed psychosis following the addition and titration of pramipexole for Parkinson’s disease. No evidence of psychosis was noted at the time of admission or prior to the addition and titration of pramipexole with good response. When titrated to 0.375 mg three times daily, psychosis presented and escalated. Pramipexole was tapered to extinction and behavior rates returned to baseline. This increase may represent a separation of risk-benefits where a partial positive response is achieved and no adverse effects are noted.