Evaluation the Activity of Enzyme Glutathione Peroxidase, Oxidative Stress Index and Some Biochemical Variables in Serum of Individuals with Obsessive-Compulsive Disorder (OCD)Author(s): Soada Mihandoust, Anahita Masoum, Maryam Moghaddam, Amir Asadi, and Zahra Hojjati Bonab*
Aim and background: Obsessive-Compulsive Disorder (OCD) is a type of mental disorder that causes discomfort and anxiety among those who suffer from this. The aim of this study was to assess glutathione peroxidase enzyme activity, oxidative stress index, and other biochemical parameters in the serum of persons with OCD.
Material and methods: In this study, the patient group consisted of 26 people with OCD, and the control group consisted of 26 healthy people. The parameters glutathione peroxidase (GSH-Px), Oxidative Stress Index (OSI), Selenium (Se), Catalase (CAT), Total Antioxidant Status (TAS), Superoxide Dismutase (SOD), Malondialdehyde (MDA), and Total Oxidant Status (TOS) were evaluated in both groups.
Results: Se, CAT, GSH-Px, and TAS were significantly higher in the healthy group than the OCD patient group (P<0.05), whereas other parameters such as SOD, MDA, TOS, and OSI were significantly higher in OCD patients than the healthy (control) group (P<0.05).
Conclusion: Depending on the results of this study, it may be concluded that a psychiatrist can determine the level of oxidative stress in a person's brain and predict suitable treatment by evaluating the amount of MDA in their plasma. Furthermore, assessing overall oxidative and antioxidant status as well as the oxidative stress coefficient is the best way to assess the overall oxidative status among healthy people, and thus this approach can prevent people from entering the OCD stage. Increasing the amount of selenium in food, relaxation, yoga, walking (jogging), and also breathing clean (healthy) air can have a very positive effect on reducing oxidative stress, which can be very effective in preventing healthy people from getting OCD.