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ISSN: 1935-1232 (P)

ISSN: 1941-2010 (E)

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Abstract

Comparative study of the effect of some new naproxen derivatives on the liver and kidney tissues of mice
Author(s): Sadiq Al-Mansury, Nabaa Hameed Chekhyor, Adnan M Jassim, Marwah Najeh hammod and Saraa Amaid kadium5

Naproxen is a phenyl propionic acid that has, anti-inflammatory, analgesic and antipyretic effects with confirmed adverse effects on most body organs involve the stomach, intestine liver, and kidneys. Often produce significant gastrointestinal, liver and kidneys tissues ulceration and bleeding, particularly in elderly patients and patients with certain co morbidities. This study aimed to assess the analgesic effects of new naproxen derivatives (which were synthesis in other study) and limitation side effects via modifying their chemical structure by addition active groups to parent compound. First step: Analysis of newly synthetized and administered naproxen-derived drugs on male albino mice (30-35 g) and distributed into five groups, the first-named negative control group. The four other groups which administered one of the synthetized compound of naproxen derivatives.