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ISSN: 1935-1232 (P)

ISSN: 1941-2010 (E)

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Abstract

Aripiprazole Lauroxil NanoCrystal Dispersion Technology (Aristada Initio)

Author(s): Megan J. Ehret, Erica Davis, Sarah E. Luttrell, Caroline Clark

Nonadherence to antipsychotic medications for the treatment of schizophrenia is a widely recognized concern, leading to poorer clinical outcomes and higher treatment costs. Long-acting injectable (LAI) antipsychotics offer an extended dosing interval option for patients, although the current options may require an oral overlap at initiation. Aripiprazole lauroxil is an LAI that offers multiple dosing options but requires oral treatment overlap during initiation for the first 21 consecutive days. As an alternative to oral overlap, a novel nano-crystalline milled dispersion delivery system of aripiprazole lauroxil was recently approved as a one-day regimen to be added to aripiprazole lauroxil treatment.